Sparkle file back-up

I want to have a back-up of my Sparkle files on a different drive. Is there any difference between duplicating the open file and save it as copy to the new drive or just copy the file in the finder (which is much faster with large sparkle files)?

Assuming there’s no unsaved changes, it’s the same thing.

Thank you Duncan. I wasn’t sure if there is something going on in the background.